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The proposed mechanism is inhibition of drug efflux via intestinal organic anion transporting polypeptides (e.P-glycoprotein), of which fexofenadine is a substrate. In a five-way crossover study with 10 healthy volunteers, 14-strength grapefruit juice, grapefruit juice, orange juice and apple juice (300 mL with drug administration and 150 mL every 12 hour for up to 3 hours, total volume 1. 2 L) reduced the mean area under the plasma concentration-time curve (AUC) of a 120 mg dose of fexofenadine by 23, 67, 72 and 77, respectively, compared to water. Mean peak plasma concentration (Cmax) was similarly affected.

74 (3), 233239. Pollard, J. and Littlejohn, R.]