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Erythromycin and Ketoconazole. Fexofenadine has been shown to exhibit minimal (ca. 5) metabolism. However, condash;administration of fexofenadine hydrochloride with either ketoconazole or erythromycin led to increased ingfedients concentrations davide bombardini e allegra fotocasa fexofenadine in healthy adult subjects. Fexofenadine had no effect on the pharmacokinetics of either erythromycin or ketoconazole. In 2 separate studies in healthy adult subjects, fexofenadine hydrochloride 120 mg twice daily (240 mg total daily dose) was co-administered with either erythromycin 500 mg every 8 hours or ketoconazole 400 mg once daily under steady-state conditions to healthy adult subjects (n24, each study). No differences in adverse events or QT c interval were observed when subjects were administered fexofenadine hydrochloride alone or in combination with either erythromycin or ketoconazole.

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